Detailed Program

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Wednesday, September 26, 2018

WELCOME RECEPTION, Dat hoghehus, Koberg 2, lübeck
17.00   Registration
17.30 Opening Words
Jörg Köhl & David A. Hildeman, Spokespersons of the IRTG
Jan Lindenau, Mayor of the City Council of Lübeck
18.15   Get together


Thursday, September 27, 2018

Lecture Hall V2, Building 61, University of Lübeck
08.30   Registration
08.45   Opening
Jörg Köhl, Spokesperson of the IRTG
Gabriele Gillessen-Kaesbach, President of the University of Lübeck
09.00 – 10.30 SESSION I: Neonatal immunoregulation in infection
Chairs:Claire Chougnet & Martin Demmert
09.00 Invited Lecture: Sing Sing Way, Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

Title: Immune pathogenesis of prenatal infection

09.45   Short Talks
 09.45 Courtney Jackson, Division of Immunobiology, Cincinnati Children’s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

Title: Emergence of inflammatory regulatory T cells with diminished suppressive function in fetal Rhesus macaques in a model of LPS-induced chorioamnionitis

10.00 Kathrin Nagel, Departement of Pediatrics; University Hospital Lübeck

Title: Regulatory T cells in preterm neonates are increased in frequency and function

10.15 Matthew Lacorcia, Institute for Medical Microbiology, Immunology and Hygiene; Technische Universität Muünchen; Germany

Title: Immune modulation through maternal Schistosoma mansoni infection

10.30 Coffee Break
11.00 – 12.30   SESSION II: Granulomatous infections
Chair: Ulrich Schaible & Lara Linnemann
11.00   Invited Lecture: Randall S. Johnson, Department of Physiology, Development and Neuroscience, University of Cambridge, United Kingdom

Title: The dichotomy of hypoxia in immune response
11.45   Short Talks
11.45 Kristina Ritter, Division of Infection Immunology, Research Center Borstel, Germany

Title: The increased protective granulomatous response in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is dependent on IL-17A and is asso- ciated with the IL-17A- induced expansion of multifunctional T cells

12.00 Melanie McKell, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

Title: L-arginine synthesis drives anti-mycobacterial aerobic glycolysis in macrophages

12.15 Dorinja Zapf, Department of Infectious Diseases and Microbiology, UKSH, Lübeck, Germany

Title: The butterfly effect in a fungal infection: Imbalance of the stress responses HIF-1α and autophagy and their contrary impact on Histoplasma capsulatum survival

12.30   Lunch
13.45 – 16.00
  SESSION III: The pleiotropic functions of innate immune cells in allergy and infection
Chair: Senad Divanovic & Caroline Hennig
13.45   Invited Lecture: Cecilia Garlanda, Humanitas Clinical Research Center, Milan, Italy

Title: Regulation of humoral innate immune responses and inflammation

14.30   Short Talks
14.30 Heidi Tackenberg, Department of Infectious Diseases and Microbiology, University of Lübeck, Germany

Title: Small GTPases of the Rho- subfamily: Regulators of neutrophil effector mechanisms or just a matter of migration?

14.45 Hanna Ulrich, Institute for Systemic Inflammation Research, University of Lübeck, Germany

Title: Targeting systemic Listeria monocytogenes to splenic CD8a DCs for the induction of cytotoxic T cells

15.00 Nestor González Roldán, DZL Junior Research Group of Allergobiochemistry, Research Center Borstel

Title: Lipid mediators derived from house dust mite potentiate allergic inflammatory responses

15.15
  Invited Lecture: Reinhard Würzner, Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Austria

Title: The role of complement in E. coli-associated haemolytic uraemic syndrome (eHUS) and considerations when to use eculizumab

16.00 – 17.45   SESSION IV: Poster Session


Friday, September 28, 2018

Lecture Hall V2, Building 61, University of Lübeck
 
08.30 – 10.00
  SESSION V: The impact of microbiome on allergic & infectious diseases
Chair: Christian Sina & Nele Twisselmann
08.30   Invited Lecture: Charles Mackay, Department of Immunology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia
Title: Diet, microbiome and disease
09.15 Julia Pagel, Departement of Pediatrics; University Hospital Lübeck, Germany, Deutsches Zentrum für Infektiosforschung (DZIF)

Title: Gut dysbiosis with Bacilli dominance and accumulation of fermentation products precedes late-onset sepsis in preterm infants

09.30 Imke Lingel, Institute of Anatomy, University of Lübeck, Germany

Title: Early life microbiota changes – increased asthma severity in mice

 09.45 Maria Nordengrün, Department of Immunology, University Medicine Greifswald, Germany

Title: S. aureus serine proteases are inducers of airway allergies

10.00   Coffee Break
10.30   SESSION VI: The immunoregulatory network of complement
Chair: Admar Verschoor & Katharina Quell
10.30   Invited Lecture: Claudia Kemper, Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, USA; Institute for Systemic Inflammation Research, University of Lübeck; School of Immunology & Microbial Sciences, King’s College London, UK
Title: The Force from within: intracellular complement and normal cell physiology
11.15 Johanna Neeb, Institute for Systemic Inflammation Research, University of Lübeck, Germany

Title: The C5a/C5aR2 axis in uterine natural killer cells controls the outcome of pregnancy

11.30 Caroline Hennig, Institute for Systemic Inflammation Research, University of Lübeck, Germany

Title: C5a receptor 2 regulated MAP kinase activation, IFN-γ production and cytotoxicity in NK cells

11.45 Konstantina Antoniou, Institute for Systemic Inflammation Research, University of Lübeck, Germany

Title: C5a receptor 1 activation controls Th cell proliferation by pulmonary CD11b+ cDC through antigen processing, MHC-II and CD40 expression

12.00   Lunch
13.15 – 15.30
  SESSION VII: The complex roles of B & T cells in allergy and infection
Chair: David Hildeman & Ireti Ogunsulire
13.15   Invited Lecture: Philippa Marrack, University of Colorado School of Medicine, Department of Biomedical Research, National Jewish Health, Denver, Colorado

Title: The specificities and functions of T and B cells

 14.00 Sabine Stegemann-Koniszewski, Infection Immunology Group, Institute of Medical Microbiology, Infection Control and Prevention, Otto-von-Guericke University Magdeburg, Germany

Title: Persistent Bordetella bronchiseptica carriage modulates the peripheral CD4+CD25+ T cell pool and differentially affects immune responses to secondary stimuli in mice

 14.15 Alexander Scheffold, Institute of Immunology, Christian- Albrechts-Universität zu Kiel, Medical Faculty Kiel, Ge many

Title: Orchestration of systemic anti-fungal Th17 immunity and immune pathology by a single member of the microbiome

14.30 Ireti Ogunsulire, Infection Immunology, Research Center Borstel, Germany

Title: Changes in cytokine signalling influences the expression of regulatory T cells with age

14.45 Invited Lecture: Sven Hammerschmidt, Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Germany

Title: Immunogenicity and protectivity of pneumococcal lipoproteins with versatile functions
15.30 – 17.15 SESSION VIII: Poster session
17.30   Closing remarks and poster award ceremony


Saturday, September 29, 2018

IRTG-internal meetings